Trehalose Metabolism

 

TPP2

We are studying the essential otsAB biosynthetic pathway responsible for the de novo biosynthesis of trehalose, which is an essential donor molecule required for the building of the mycobacterial outer membrane.

GlgE

GlgE is  a maltosyl-transferase important for the biosynthesis of the mycobacterial glucan and is a genetically validated TB drug target. We are using structure-based design to develop new inhibitors.

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Antigen 85

The antigen 85 enzymes are essential for the viability of M. tuberculosis, we are studying their enzymatic activity, substrate specificity, and inhibition in collaboration with Dr. Steve Sucheck (University of Toledo).