Mycobacterial Xenobiotic Metabolism


M. tuberculosis synthesizes large amounts of mycothiol to maintain a strongly reductive cytosol. In addition, mycobacteria use mycothiol as a molecular flag to promote the efflux of drug molecules from the bacterial cytosol in a manner analogous to that of glutathione in many other organisms. We are studying the structure/function relationship of mycothiol biosynthetic enzymes and the Mycothiol Transferase that modifies small molecule anti-tubercular compounds with mycothiol.


 Jimmy and Brittney sciencing.