Mycobacterial Xenobiotic Metabolism

 

M. tuberculosis synthesizes large amounts of mycothiol to maintain a strongly reductive cytosol. In addition, mycobacteria use mycothiol as a molecular flag to promote the efflux of drug molecules from the bacterial cytosol in a manner analogous to that of glutathione in many other organisms. We are studying the structure/function relationship of mycothiol biosynthetic enzymes and the Mycothiol Transferase that modifies small molecule anti-tubercular compounds with mycothiol.

 

 
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Jimmy and Brittney sciencing.