Christopher M. Goins, Steven J. Dajnowicz, Sandeep Thanna, Steven J. Sucheck, Jerry Matthew Parks, and Donald R Ronning. Exploring Covalent Allosteric Inhibition of Antigen 85C from Mycobacterium tuberculosis by Ebselen Derivatives. (2017) ACS Infectious Diseases. doi: 10.1021/acsinfecdis.7b00003. [Epub ahead of print].

Sandeep Thanna, Christopher M Goins, Susan E Knudson, Richard A Slayden, Donald R Ronning, and Steven J Sucheck. Thermal and photoinduced copper-promoted C-Se bond formation: Synthesis of 2-alkyl-1,2-benzisoselenazol-3(2H)-ones and evaluation against Mycobacterium tuberculosis. (2017) J Org Chem. doi: 10.1021/acs.joc.7b00440. [Epub ahead of print].

Michael T Banco, Vidhi Mishra , Andreas Ostermann, Tobias E Schrader, Gary B Evans, Andrey Kovalevsky, and Donald R Ronning. Neutron structures of the Helicobacter pylori 5'-methylthioadenosine nucleosidase highlight proton sharing and protonation states. (2016) Proc Natl Acad Sci USA. 113(48):13756-61.

Anna E. Grzegorzewicz, Célia de Sousa-d'Auria, Michael R. McNeil, Emilie Huc-Claustre, Victoria Jones, Cécile Petit, Shiva kumar Angala, Júlia Zemanová, Qinglan Wang, Juan Manuel Belardinelli, Qian Gao, Yoshimasa Ishizaki, Katarína Mikušová, Patrick J. Brennan, Donald R. Ronning, Mohamed Chami, Christine Houssin and Mary Jackson. Assembling of the Mycobacterium tuberculosis Cell Wall Core. (2016) J Biol Chem. 291(36):18867-79.

Sandeep Thanna, Susan E Knudson, Anna Grzegorzewicz, Sunayana Kapil, Christopher M Goins, Donald R Ronning, Mary Jackson, Richard A Slayden, Steven J Sucheck. Synthesis and evaluation of new 2-aminothiophenes against Mycobacterium tuberculosis. (2016) Org Biomol Chem. 14(25):6119-33.

Jared J. Lindenberger, Sri Kumar Veleti, Sandeep Thanna, Britney Wilson, Steven J. Sucheck, and Donald R. Ronning. Crystal structures of Mycobacterium tuberculosis GlgE and complexes with non-covalent inhibitors. (2015) Sci. Reports5:12830. doi: 10.1038/srep12830. PDF

Sandeep Thanna†, Jared J. Lindenberger†, Vishwanath V. Gaitonde , Donald R. Ronning* and Steven J. Sucheck*. Synthesis of 2-deoxy-2,2-difluoro-a-maltosyl fluoride and its X-ray structure in complex with Streptomyces coelicolor GlgEI-V279S. Organic & Biomolecular Chemistry (2015) DOI: 10.1039/C5OB00867K. PDF

Kevin D. Clark, Omprakash Nacham, Honglian Yu, Tianhao Li, Donald R. Ronning, and Jared L. Anderson. Extraction of DNA by Magnetic Ionic Liquids: Tunable Solvents for Rapid and Selective DNA Analysis. Analytical Chemistry (2015) 87(3):1552–1559 DOI: 10.1021/ac504260t. PDF

Anna E Grzegorzewicz, Nathalie Eynard, Annaïk Quemard, E Jeffrey North, Alyssa Margolis, Jared J Lindenberger, Victoria Jones, Jana Kordulakova, Patrick J. Brennan, Richard E Lee, Donald R Ronning, Michael McNeil, and Mary Jackson. Covalent modification of the Mycobacterium tuberculosis FAS-II dehydratase by Isoxyl and Thiacetazone. ACS Infectious Diseases. (2014). DOI:10.1021/id500032q. PDF

Tripti Anadan, Jaeil Han, Heather Baun, Seeta Nyayapathy, Jacob T. Brown, Rebekah L. Dial, Juan A. Moltalvo, Min-Seon Kim, Seung Hwan Yang, Donald R. Ronning, Robert N. Husson, Joowon Suh and Choong-Min Kang. Phosphorylation Regulates Mycobacterial Proteasome. J Microbiol. (2014) 52(9): 743-54. PDF

Sri Kumar Veleti, Jared J. Lindenberger, Sandeep Thanna, Donald R. Ronning, Steven J. Sucheck Synthesis of a poly-hydroxypyrolidine-based inhibitor of Mycobacterium tuberculosis GlgE. J Org Chem. (2014) 79(20): 9444-50. Featured article. PDF

Lorenza Favrot, Daniel H. Lajiness, and Donald R. Ronning. Inactivation of the Mycobacterium tuberculosis Antigen 85 complex by covalent, allosteric inhibitors. J. Biol. Chem. (2014) 289(36): 25031-40. PDF

Sri Kumar Veleti, Jared J. Lindenberger, Donald R. Ronning, Steven J. Sucheck. Synthesis of a C-phosphonate mimic of maltose-1-phosphate and inhibition studies on Mycobacterium tuberculosis GlgE. Bioorg. Med. Chem. (2014) 22(4):1404-11. PDF

Lorenza Favrot, Anna E. Grzegorzewicz, Daniel H. Lajiness, Rachel K. Marvin, Julie Boucau, Dragan Isailovic, Mary Jackson, Donald R. Ronning. The inhibition mechanism of Mycobacterium tuberculosis Antigen 85 by ebselen. Nat. Commun. (2013) 4:2748 doi: 10.1038/ncomms3748. Faculty of 1000 recommended. PDF

Lucile Pinault, Jeong-Sun Han, Choong-min Kang, Jimmy Franco, and Donald R. Ronning. Zafirlukast inhibits complexation of Lsr2 with DNA and growth of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. (2013) 57: 2134-40. PDF

Tianhao Li, Manishkumar D. Joshi, Donald R. Ronning, Jared L. Anderson. Ionic liquids as solvents for in situ dispersive liquid-liquid microextraction of DNA. J. Chromatogr. A (2013) 1272: 8-14. PDF

Diaa A. Ibrahim, Julie Boucau, Daniel Lajiness, Sri Kumar Veleti, Kevin R. Trabbic, Samuel S. Adams, Donald R. Ronning and Steven J. Sucheck. Design, synthesis and X-ray analysis of a glycoconjugate bound to Mycobacterium tuberculosis Antigen 85CBioconjugate Chem. (2012) 23: 2403-16. PDF

Vidhi Mishra and Donald R. Ronning. Crystal structures of the Helicobacter pylori MTAN enzyme reveal specific interactions between S-adenosylhomocysteine and the 5'-alkylthio binding sub-site. Biochemistry, (201251: 9763–9772. PDF

Lorenza Favrot, Donald R. Ronning. Targeting the mycobacterial envelope for tuberculosis drug development. Expert Rev Anti Infect Ther. (2012) 10(9): 1023-36. PDF

Donald R. Ronning, Natalie M. Iacopelli, and Vidhi Mishra. Enzyme-ligand interactions that drive active site rearrangements in the Helicobacter pylori 5’-methylthioadenosine/S-adenosylhomocysteine nucleosidase. Protein Sci. (2010) 19(12): 2498-510. PDF

Francis E. Umesiri, Aditya Sanki, Julie Boucau, Donald R. Ronning, Steve Sucheck. Recent advances toward the inhibition of mAG and LAM synthesis in Mycobacterium tuberculosis. Med Res Rev. (2010) 30(2): 290-326. PDF

Aditya Sanki, Julie Boucau, Francis E. Umesiri, Donald R. Ronning, Steve Sucheck. Design, synthesis and biological evaluation of sugar-derived esters, alpha-ketoesters and alpha-ketoamides as inhibitors for Mycobacterium tuberculosis antigen 85CMol Biosyst. (2009) 5(9): 945-956. PDF

Aditya Sanki, Julie Boucau, Donald R. Ronning, Steve Sucheck. Antigen 85C-Mediated Acyl-Transfer between Synthetic Acyl Donors and Fragments of the Arabinan. Glycoconjugate J. (2009) 26(5): 589-596. PDF

Julie Boucau, Aditya Sanki, Brad Voss, Steve Sucheck, Donald R. Ronning. A Coupled Enzymatic Assay Measuring M. tuberculosis Antigen 85C Activity. Anal. Biochem. (2009) 385(1): 120-127. PDF

Aditya Sanki, Julie Boucau, Parajat Srivastava, Samual Adams, Donald R. Ronning, Steve Sucheck. Synthesis of methyl 5-S-alkyl-5-thio-D-arabinofuranosides and evaluation of their antimycobacterial activity. Bioorg Med Chem. (2008) 16: 5672-5682. PDF

Orsolya Barabas, Donald R. Ronning, Catherine Guynet, Alison Burgess Hickman, Bao Ton-Hoang, Michael Chandler, Fred Dyda. Mechanism of IS200/IS605 Family DNA Transposases: Activation and Transposon-Directed Target Site Selection. Cell, (2008) 132: 208-220. PDF

Donald R. Ronning, Catherine Guynet, Bao Ton-Hoang, Zhanita N. Perez, Rodolfo Ghirlando, Michael Chandler, Fred Dyda. Active Site Sharing and Subterminal Hairpin Recognition in a New Class of DNA Transposases.  Mol. Cell (2005) 20: 143-154. PDF

Bao Ton-Hoang, Catherine Guynet, Donald R. Ronning, Brigitte Cointin-Marty, Fred Dyda, Michael Chandler. Transposition of ISHp608, member of an unusual family of bacterial Insertion sequences. EMBO J. (2005) 24: 3325-3338. PDF

Christina M. Bradley, Donald R. Ronning, Rodolfo Ghirlando, Robert Craigie, Fred Dyda. Structural basis for DNA Bridging by barrier-to-autointegration factor. Nat. Struct. Mol. Biol. (2005) 12: 935-936. PDF

Kuppan Gokulan, Sangeeta Khare, Donald R. Ronning, Scott D. Linthicum, James C. Sacchettini, Bernhard Rupp. Cocrystal Structures of NC6.8 Fab Identify Key Interactions for High Potency Sweetener Recognition: Implications for the Design of Synthetic Sweeteners. Biochemistry (2005) 44: 9889-9898. PDF

Donald R. Ronning, Ying Li, Zhanita N. Perez, Philip D. Ross, Alison Burgess Hickman, Nancy L. Craig, Fred Dyda. The carboxy-terminal portion of TnsC activates the Tn7 transposase through a specific interaction with TnsA. EMBO J. (2004) 23: 2972–2981. PDF

Donald R. Ronning, Varalakshmi Vissa, Gurdyal S. Besra, John T. Belisle, James C. Sacchettini. Mycobacterium tuberculosis antigen 85A and 85C structures confirm Binding orientation and conserved substrate specificity. J. Biol. Chem. (2004) 279: 36771-36777. PDF

Alison Burgess Hickman, Donald R. Ronning, Zhanita N. Perez, Robert M. Kotin, Fred Dyda. The Nuclease Domain of Adeno-Associated Virus Rep Coordinates Replication Initiation Using Two Distinct DNA Recognition Interfaces. Mol. Cell. (2004) 13: 403-414. PDF

Vivek Sharma, Arulandu Arockiasamy, Donald R. Ronning, Christos G. Savva, Andreas Holzenburg, Miriam Braunstein, William R. Jacobs Jr, James C. Sacchettini. Crystal structure of Mycobacterium tuberculosis SecA, a preprotein translocating ATPase. Proc. Natl. Acad. Sci. U. S. A. (2003) 100: 2243-2248. PDF

Michelle R. Riley-Lovingshimer, Donald R. Ronning, James C. Sacchettini, Gregory D. Reinhart.  Reversible ligand-induced dissociation of a tryptophan-shift mutant of phosphofructokinase from Bacillus stearothermophilus. Biochemistry. (2002) 41: 12967-12974. PDF

Alison Burgess Hickman, Donald R. Ronning, Robert M. Kotin, Fred Dyda. Structural unity among viral origin binding proteins: crystal structure of the nuclease domain of adeno-associated virus Rep. Mol. Cell. (2002) 10: 327-337. PDF

Donald R. Ronning, Thomas Klabunde, Gurdyal S. Besra, Varalakshmi Vissa, John T. Belisle, James C. Sacchettini. Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines. Nat. Struct. Mol. Biol. (2000) 7: 141-146. PDF

Ronan O’Hagen, Nicole Schreiber-Agus, Ken Chen, Gregory David, Jeffrey A. Engelman, Richard Schwab, Leila Alland, Cole Thomson, Donald R. Ronning, James C. Sacchettini, Paul Meltzer, Ronald A. DePinho. Gene-target recognition among members of the myc superfamily and implications for oncogenesis. Nat. Genet. (2000) 24: 113-119. PDF